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A population-based study of Coats disease in the United Kingdom II: investigation, treatment, and outcomes.
[coats disease]
coats
disease
is
an
uncommon
form
of
retinal
telangiectasia
.
We
conducted
a
prospective
population-based
study
of
Coats
disease
in
the
United
Kingdom
to
provide
a
more
balanced
picture
.
This
paper
reports
the
investigations
and
treatments
used
for
Coats
disease
and
their
anatomic
and
visual
outcomes
.
the
study
was
conducted
through
the
British
Ophthalmic
Surveillance
Unit
.
All
ophthalmologists
notifying
cases
of
Coats
disease
were
sent
a
baseline
questionnaire
and
a
follow-up
questionnaire
after
6
months
.
in
total
,
55
baseline
and
42
follow-up
questionnaires
were
returned
.
All
cases
were
unilateral
.
Ultrasound
was
performed
in
26
%
of
cases
,
fluorescein
angiography
in
35
%
,
and
examination
under
anaesthesia
in
42
%
of
the
cases
.
Laser
photocoagulation
was
by
far
the
primary
treatment
modality
,
used
in
92
%
,
with
cryotherapy
used
mainly
as
a
second
-line
or
adjunctive
treatment
.
In
more
advanced
cases
with
significant
retinal
detachment
,
laser
photocoagulation
combined
with
pars
plana
vitrectomy
and
drainage
of
sub-
retinal
fluid
can
produce
anatomic
stability
and
prevent
progress
to
end-
stage
disease
.
Intravitreal
injections
of
steroids
or
VEGF
inhibitors
are
currently
of
unproven
efficacy
in
Coats
disease
.
Overall
,
treatment
resulted
in
stabilisation
of
visual
acuity
.
Anatomic
stabilisation
or
improvement
was
achieved
in
virtually
all
eyes
.
laser
photocoagulation
to
telangiectatic
retinal
vessels
is
the
most
commonly
used
treatment
for
Coats
disease
.
Other
treatments
are
either
adjunctive
or
of
unproven
efficacy
.
A
realistic
treatment
goal
is
to
achieve
anatomic
stability
and
avoidance
of
enucleation
for
painful
end-
stage
disease
.
Visual
improvement
is
however
unlikely
.
Diseases
Validation
Diseases presenting
"advanced cases"
symptom
coats disease
esophageal carcinoma
oral submucous fibrosis
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