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Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction.
[coats disease]
To
evaluate
the
effect
of
supplemental
intravitreal
bevacizumab
for
management
of
Coats
'
disease
.
Retrospective
analysis
of
eight
patients
with
Coats
'
disease
manifesting
total
or
partial
exudative
retinal
detachment
where
the
retinal
telangiectasia
was
treated
with
standard
laser
photocoagulation
and
/
or
cryotherapy
plus
additional
intravitreal
bevacizumab
(
1
.
25
mg
/
0
.
05
ml
)
.
The
mean
patient
age
was
88
(
range
7
-
240
)
months
and
63
%
were
male
.
Coats
'
disease
was
classified
as
stage
2
(
n
=
1
,
12
%
)
,
3
a
(
n
=
3
,
38
%
)
and
3
b
(
n
=
4
,
50
%
)
.
Features
included
retinal
detachment
(
n
=
8
,
100
%
with
mean
detachment
extent
involving
8
clock
hours
)
,
telangiectasia
(
n
=
8
,
100
%
with
mean
extent
of
8
clock
hours
)
,
peripheral
retinal
ischaemia
on
fluorescein
angiography
(
n
=
7
,
88
%
)
and
no
evidence
of
neovascularisation
.
Treatment
consisted
of
cryotherapy
(
n
=
8
,
100
%
)
,
laser
photocoagulation
(
n
=
4
,
50
%
)
and
bevacizumab
intravitreal
injection
(
n
=
8
)
with
median
number
of
one
injection
per
eye
(
mean
1
.
75
,
and
range
1
-
4
injections
)
.
After
a
mean
follow-up
of
8
.
5
months
,
resolution
of
retinopathy
(
n
=
8
,
100
%
)
,
Coats
'
-
related
subretinal
fluid
(
n
=
8
,
100
%
)
and
retinal
exudation
(
n
=
6
,
75
%
)
was
noted
.
However
,
vitreous
fibrosis
developed
(
n
=
4
,
50
%
)
at
a
mean
of
5
months
following
a
mean
of
1
.
75
bevacizumab
injections
with
three
(
38
%
)
evolving
into
traction
retinal
detachment
.
Coats
'
disease
treated
with
intravitreal
bevacizumab
in
addition
to
standard
therapy
can
develop
to
vitreoretinal
fibrosis
and
potentially
traction
retinal
detachment
.
These
tractional
features
are
not
often
found
in
Coats
'
disease
treated
with
standard
measures
without
bevacizumab
.
Caution
is
advised
in
the
use
of
bevacizumab
for
patients
with
Coats
'
disease
.
Diseases
Validation
Diseases presenting
"retinal detachment"
symptom
aniridia
coats disease
von hippel-lindau disease
werner syndrome
This symptom has already been validated
