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Increased nitric oxide and vascular endothelial growth factor levels in the aqueous humor of patients with coats' disease.
[coats disease]
To
determine
the
aqueous
humor
levels
of
nitric
oxide
(
NO
)
and
vascular
endothelial
growth
factor
(
VEGF
)
in
the
eyes
of
patients
with
Coats
'
disease
and
study
the
correlation
between
these
levels
.
Samples
of
aqueous
humor
were
obtained
from
7
patients
with
Coats
'
disease
and
15
age-matched
patients
with
congenital
cataracts
as
controls
.
Nitrite
and
nitrate
(
NOx
)
,
the
stable
end
products
of
NO
,
were
detected
by
the
Griess
reaction
,
and
VEGF
levels
were
assessed
by
enzyme-linked
immunosorbent
assay
.
The
aqueous
humor
NOx
and
VEGF
levels
were
elevated
in
the
eyes
of
patients
with
Coats
'
disease
compared
with
those
of
controls
(
P
=
0
.
001
and
P
<
0
.
001
,
respectively
)
.
The
median
NOx
level
was
55
.
2
 
μM
(
range
,
23
.
0
-
75
.
3
 
μM
)
in
the
Coats
'
disease
group
and
18
.
8
 
μM
(
range
,
8
.
7
-
36
.
2
 
μM
)
in
the
control
group
.
The
median
VEGF
level
was
731
.
7
 
pg
/
mL
(
range
,
288
.
3
-
1364
.
3
 
pg
/
mL
)
in
the
Coats
'
disease
group
and
33
.
3
 
pg
/
mL
(
range
,
9
.
0
-
96
.
8
 
pg
/
mL
)
in
the
control
group
.
No
correlation
was
observed
between
the
aqueous
humor
concentrations
of
NOx
and
VEGF
.
NOx
and
VEGF
are
increased
but
not
related
in
the
aqueous
humor
samples
of
patients
with
Coats
'
disease
.
NO
and
VEGF
may
play
roles
in
the
pathogenesis
of
Coats
'
disease
.
Further
studies
are
needed
to
clearly
elucidate
the
relationship
among
VEGF
,
NO
,
and
other
cytokines
in
Coats
'
disease
.
Diseases
Validation
Diseases presenting
"clearly elucidate"
symptom
coats disease
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