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Increased nitric oxide and vascular endothelial growth factor levels in the aqueous humor of patients with coats' disease.
[coats disease]
To
determine
the
aqueous
humor
levels
of
nitric
oxide
(
NO
)
and
vascular
endothelial
growth
factor
(
VEGF
)
in
the
eyes
of
patients
with
Coats
'
disease
and
study
the
correlation
between
these
levels
.
Samples
of
aqueous
humor
were
obtained
from
7
patients
with
Coats
'
disease
and
15
age-matched
patients
with
congenital
cataracts
as
controls
.
Nitrite
and
nitrate
(
NOx
)
,
the
stable
end
products
of
NO
,
were
detected
by
the
Griess
reaction
,
and
VEGF
levels
were
assessed
by
enzyme-linked
immunosorbent
assay
.
The
aqueous
humor
NOx
and
VEGF
levels
were
elevated
in
the
eyes
of
patients
with
Coats
'
disease
compared
with
those
of
controls
(
P
=
0
.
001
and
P
<
0
.
001
,
respectively
)
.
The
median
NOx
level
was
55
.
2
 
μM
(
range
,
23
.
0
-
75
.
3
 
μM
)
in
the
Coats
'
disease
group
and
18
.
8
 
μM
(
range
,
8
.
7
-
36
.
2
 
μM
)
in
the
control
group
.
The
median
VEGF
level
was
731
.
7
 
pg
/
mL
(
range
,
288
.
3
-
1364
.
3
 
pg
/
mL
)
in
the
Coats
'
disease
group
and
33
.
3
 
pg
/
mL
(
range
,
9
.
0
-
96
.
8
 
pg
/
mL
)
in
the
control
group
.
No
correlation
was
observed
between
the
aqueous
humor
concentrations
of
NOx
and
VEGF
.
NOx
and
VEGF
are
increased
but
not
related
in
the
aqueous
humor
samples
of
patients
with
Coats
'
disease
.
NO
and
VEGF
may
play
roles
in
the
pathogenesis
of
Coats
'
disease
.
Further
studies
are
needed
to
clearly
elucidate
the
relationship
among
VEGF
,
NO
,
and
other
cytokines
in
Coats
'
disease
.
Diseases
Validation
Diseases presenting
"growth factor"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenal incidentaloma
aniridia
cadasil
cholangiocarcinoma
coats disease
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
holt-oram syndrome
inclusion body myositis
kallmann syndrome
krabbe disease
liposarcoma
lymphangioleiomyomatosis
oculocutaneous albinism
oral submucous fibrosis
pleomorphic liposarcoma
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
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