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An evidence-based review of vascular endothelial growth factor inhibition in pediatric retinal diseases: part 2. Coats' disease, best disease, and uveitis with childhood neovascularization.
[coats disease]
Vascular
endothelial
growth
factor
(
VEGF
)
is
an
important
factor
in
the
pathogenesis
of
multiple
retinal
neovascular
disorders
.
This
report
focuses
on
the
quality
and
depth
of
new
evidence
for
the
use
of
VEGF
inhibitors
in
selected
pediatric
ocular
diseases
,
including
Coats
'
disease
,
Best
disease
,
and
childhood
uveitis
.
Because
much
of
the
literature
comprises
case
reports
and
retrospective
case
series
,
the
level
of
evidence
supporting
its
use
as
a
primary
treatment
option
,
or
even
as
adjuvant
therapy
,
is
low
.
The
standard
of
care
is
treatment
of
the
underlying
disorder
to
prevent
neovascularization
(
retinal
or
subretinal
)
,
vitreous
hemorrhage
,
or
subsequent
retinal
detachment
.
However
,
these
complications
may
not
present
until
late
in
the
disease
course
.
It
may
then
be
useful
to
treat
with
these
agents
.
Prospective
studies
are
warranted
to
further
elucidate
the
role
of
anti-
VEGF
therapy
in
these
diseases
.
Diseases
Validation
Diseases presenting
"vitreous hemorrhage"
symptom
coats disease
This symptom has already been validated
