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Lesions simulating retinoblastoma (pseudoretinoblastoma) in 604 cases: results based on age at presentation.
[coats disease]
To
determine
the
types
and
frequency
of
ocular
conditions
that
simulate
retinoblastoma
(
pseudoretinoblastoma
)
based
on
age
at
presentation
.
Retrospective
case
series
.
Two
thousand
seven
hundred
seventy-
five
patients
.
Chart
review
.
Conditions
simulating
retinoblastoma
.
Of
2775
patients
referred
for
management
of
retinoblastoma
,
2171
patients
(
78
%
)
had
confirmed
retinoblastoma
and
604
patients
(
22
%
)
had
simulating
lesions
(
pseudoretinoblastomas
)
.
In
the
pseudoretinoblastoma
cohort
,
the
mean
patient
age
at
presentation
was
4
years
(
median
,
2
years
)
.
There
were
27
different
pseudoretinoblastoma
conditions
,
and
the
10
most
common
included
Coats
'
disease
(
n
=
244
;
40
%
)
,
persistent
fetal
vasculature
(
PFV
;
n
=
158
;
28
%
)
,
vitreous
hemorrhage
(
n
=
27
;
5
%
)
,
ocular
toxocariasis
(
n
=
22
;
4
%
)
,
familial
exudative
vitreoretinopathy
(
FEVR
;
n
=
18
;
3
%
)
,
rhegmatogenous
retinal
detachment
(
n
=
18
;
3
%
)
,
coloboma
(
n
=
17
;
3
%
)
,
astrocytic
hamartoma
(
n
=
15
;
2
%
)
,
combined
hamartoma
of
retina
and
retinal
pigment
epithelium
(
n
=
15
;
2
%
)
,
and
endogenous
endophthalmitis
(
n
=
10
;
2
%
)
.
Simulating
lesions
differed
based
on
age
at
presentation
,
and
children
younger
than
1
year
were
most
likely
to
have
PFV
(
49
%
)
,
Coats
'
disease
(
20
%
)
,
or
vitreous
hemorrhage
(
7
%
)
;
those
2
to
5
years
of
age
were
most
likely
to
have
Coats
'
disease
(
61
%
)
,
toxocariasis
(
8
%
)
,
or
PFV
(
7
%
)
;
and
those
older
than
5
years
were
most
likely
to
have
Coats
'
disease
(
57
%
)
,
toxocariasis
(
8
%
)
,
or
FEVR
(
6
%
)
.
The
most
common
pseudoretinoblastomas
include
Coats
'
disease
,
PFV
,
and
vitreous
hemorrhage
,
but
the
spectrum
varies
depending
on
patient
age
.
Diseases
Validation
Diseases presenting
"common pseudoretinoblastomas"
symptom
coats disease
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