Expression of vascular endothelial growth factor in eyes with Coats' disease.

[coats disease]

To examine the expression of vascular endothelial growth factor (VEGF ) and VEGF receptor (VEGFR )-2 in enucleated eyes with Coats ' disease .Formalin-fixed , paraffin-embedded tissue sections from nine globes with Coats ' disease were submitted for hematoxylin and eosin staining and immunohistochemistry with anti-VEGF and VEGFR antibodies .H istologically , the enucleated eyes demonstrated the presence of macrophage infiltration and cholesterol clefts in the subretinal space . There were marked retinal vascular abnormalities , including dilated vessels with hyalinized vessel walls in six globes . Exudative retinal detachment was noted in all globes . VEGF immunoreactivity was observed in macrophages infiltrating the subretinal space , and in the detached retina including several blood vessels . VEGF-positivity in macrophages was significantly higher in cases containing retinal vessel abnormalities than those without the abnormalities (P < 0 .01 ). VEGFR-2 immunoreactivity was detected in endothelial cells lining the abnormal retinal vessels , where VEGFR-1 or VEGFR-3 was not expressed .Immunoreactivity for VEGF and VEGFR-2 was detected in macrophages and endothelia of abnormal vessels in eyes with Coats ' disease . These results suggest that anti-VEGF approach is a promising therapy for patients with Coats ' disease .

Diseases
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Diseases presenting "including dilated vessels with hyalinized vessel walls in six globes" symptom

coats disease

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