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Successful use of intravitreal bevacizumab and pascal laser photocoagulation in the management of adult Coats' disease.
[coats disease]
Traditional
methods
of
managing
exudative
retinal
detachment
secondary
to
Coats
'
disease
have
been
associated
with
varying
degrees
of
success
.
We
describe
a
case
of
a
34
year
-old
male
who
presented
with
a
sub-
total
exudative
retinal
detachment
of
the
right
eye
that
encroached
upon
the
macula
,
associated
with
a
vasoproliferative
tumor
secondary
to
Coats
'
disease
.
The
patient
under-went
successful
treatment
with
two
intravitreal
injections
of
bevacizumab
(
Avastin
,
Genetech
Inc
.
,
San
Francisco
,
CA
,
USA
)
combined
with
targeted
laser
photocoagulation
with
a
532
nm
Pascal
laser
(
Topcon
Corp
.
,
Tokyo
,
Japan
)
.
The
visual
acuity
improved
5
days
after
the
second
intravitreal
injection
from
6
/
18
to
6
/
5
,
with
no
residual
macular
edema
and
complete
regression
of
the
vasoproliferative
tumor
.
The
improvement
in
visual
acuity
was
maintained
at
12
months
post-treatment
.
We
believe
this
is
the
first
case
report
describing
the
successful
use
of
Pascal
laser
photocoagulation
with
intravitreal
bevacizumab
in
the
treatment
of
Coats
'
disease
.
Our
aim
was
to
defer
laser
treatment
until
'
near
total
'
retinal
reattachment
and
regression
of
the
vasoproliferative
tumor
was
achieved
.
There
are
,
however
,
reports
of
vitreous
fibrosis
in
patients
with
Coats
'
disease
treated
with
intravitreal
bevacizumab
.
This
suggests
further
long
-term
follow-up
studies
are
required
in
patients
treated
with
this
approach
.
Diseases
Validation
Diseases presenting
"under-went successful treatment"
symptom
coats disease
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