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Successful use of intravitreal bevacizumab and pascal laser photocoagulation in the management of adult Coats' disease.
[coats disease]
Traditional
methods
of
managing
exudative
retinal
detachment
secondary
to
Coats
'
disease
have
been
associated
with
varying
degrees
of
success
.
We
describe
a
case
of
a
34
year
-old
male
who
presented
with
a
sub-
total
exudative
retinal
detachment
of
the
right
eye
that
encroached
upon
the
macula
,
associated
with
a
vasoproliferative
tumor
secondary
to
Coats
'
disease
.
The
patient
under-went
successful
treatment
with
two
intravitreal
injections
of
bevacizumab
(
Avastin
,
Genetech
Inc
.
,
San
Francisco
,
CA
,
USA
)
combined
with
targeted
laser
photocoagulation
with
a
532
nm
Pascal
laser
(
Topcon
Corp
.
,
Tokyo
,
Japan
)
.
The
visual
acuity
improved
5
days
after
the
second
intravitreal
injection
from
6
/
18
to
6
/
5
,
with
no
residual
macular
edema
and
complete
regression
of
the
vasoproliferative
tumor
.
The
improvement
in
visual
acuity
was
maintained
at
12
months
post-treatment
.
We
believe
this
is
the
first
case
report
describing
the
successful
use
of
Pascal
laser
photocoagulation
with
intravitreal
bevacizumab
in
the
treatment
of
Coats
'
disease
.
Our
aim
was
to
defer
laser
treatment
until
'
near
total
'
retinal
reattachment
and
regression
of
the
vasoproliferative
tumor
was
achieved
.
There
are
,
however
,
reports
of
vitreous
fibrosis
in
patients
with
Coats
'
disease
treated
with
intravitreal
bevacizumab
.
This
suggests
further
long
-term
follow-up
studies
are
required
in
patients
treated
with
this
approach
.
Diseases
Validation
Diseases presenting
"edema"
symptom
acute rheumatic fever
adrenomyeloneuropathy
aniridia
cadasil
canavan disease
classical phenylketonuria
coats disease
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
erythropoietic protoporphyria
esophageal carcinoma
fabry disease
familial mediterranean fever
focal myositis
harlequin ichthyosis
homocystinuria without methylmalonic aciduria
inclusion body myositis
lamellar ichthyosis
liposarcoma
lymphangioleiomyomatosis
malignant atrophic papulosis
pleomorphic liposarcoma
systemic capillary leak syndrome
trochlear dysplasia
von hippel-lindau disease
waldenström macroglobulinemia
This symptom has already been validated
