Rare Diseases Symptoms Automatic Extraction
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Clinical misdiagnosis of retinoblastoma in Indian children.
[coats disease]
To
determine
the
rate
of
clinical
misdiagnosis
in
paediatric
patients
who
were
enucleated
for
retinoblastoma
and
report
the
clinicopathological
features
of
cases
that
were
misdiagnosed
.
Retrospective
review
of
medical
records
of
children
who
underwent
a
primary
enucleation
for
advanced
retinoblastoma
was
done
.
In
all
cases
,
the
diagnosis
of
retinoblastoma
was
made
on
the
basis
of
clinical
presentation
and
imaging
modalities
.
Clinicopathological
features
of
eyes
with
discordant
clinical
and
histopathological
diagnosis
were
studied
in
detail
.
Of
280
eyes
(
280
patients
)
that
were
enucleated
over
a
4
-
year
period
,
histopathological
diagnosis
was
consistent
with
retinoblastoma
in
276
(
98
.
6
%
)
eyes
.
In
4
(
1
.
4
%
)
eyes
,
clinical
and
histopathological
diagnoses
were
discordant
.
Histopathological
features
in
misdiagnosed
cases
included
one
case
each
of
granulomatous
endophthalmitis
,
retinal
astrocytoma
,
Coats
'
disease
and
persistent
hyperplastic
primary
vitreous
.
To
the
best
of
our
knowledge
,
this
is
the
first
study
to
examine
the
rate
of
clinical
misdiagnosis
of
retinoblastoma
from
South
Asia
.
Despite
the
use
of
modern
preoperative
imaging
modalities
including
MRI
scans
,
benign
lesions
in
end-
stage
conditions
simulated
retinoblastoma
,
resulting
in
potentially
avoidable
enucleation
.