Large neutral amino acid therapy and phenylketonuria: a promising approach to treatment.

[classical phenylketonuria]

Six subjects with classical phenylketonuria (PKU ) were treated with large neutral amino acid supplements (PreKUnil , Nilab , Dk ) at 0 .4 g /kg /day in equally divided doses three times each day on an increased natural protein diet . All six subjects had low or deficient blood concentrations of both tyrosine and tryptophan , which are precursors for dopamine and serotonin , respectively , at the beginning of the study and were increased substantially throughout the study . Blood phenylalanine concentrations remained essentially unchanged , while the brain phenylalanine concentrations gradually decreased toward the carrier range as seen in parents of children with PKU . Two subjects were diagnosed with clinical depression and were in counseling programs at initiation of the study . At the end of the study all patients reported increased energy and overall improvement in well-being .

Diseases
Validation

Diseases presenting "depression" symptom

22q11.2 deletion syndrome

achondroplasia

adrenal incidentaloma

adrenomyeloneuropathy

alexander disease

aromatase deficiency

cadasil

child syndrome

classical phenylketonuria

congenital adrenal hyperplasia

congenital toxoplasmosis

cushing syndrome

cutaneous mastocytosis

dracunculiasis

fabry disease

familial hypocalciuric hypercalcemia

gm1 gangliosidosis

hereditary cerebral hemorrhage with amyloidosis

krabbe disease

locked-in syndrome

malignant atrophic papulosis

oligodontia

oral submucous fibrosis

phenylketonuria

sneddon syndrome

triple a syndrome

trochlear dysplasia

von hippel-lindau disease

This symptom has already been validated