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A random Abstract
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Outcomes in biliary malignancy.
[cholangiocarcinoma]
The
biliary
malignancies
that
are
reviewed
here
are
gallbladder
cancer
(
GBC
)
,
intrahepatic
cholangiocarcinoma
(
IHC
)
,
and
perihilar
cholangiocarcinoma
(
PHC
)
.
The
focus
is
on
outcomes
after
potentially
curative
resection
of
biliary
malignancies
.
Key
outcomes
are
postoperative
mortality
,
median
and
5
-
year
overall
survival
(
OS
)
,
recurrence-free
survival
,
and
recurrence
patterns
.
Poor
prognostic
factors
for
recurrence
and
survival
as
well
as
prognostic
models
are
also
discussed
.
The
incidence
of
biliary
malignancies
in
the
United
States
is
about
5
in
100
,
000
.
Postoperative
mortality
for
resection
of
GBC
and
IHC
is
similar
to
that
of
liver
resections
for
other
indications
.
However
,
90
day
postoperative
mortality
after
liver
resection
for
PHC
is
about
10
%
.
For
GBC
,
median
OS
depends
strongly
on
the
T
-
stage
and
ranges
from
8
months
(
pT
3
)
to
79
months
(
pT
1
b
)
.
Median
OS
after
resection
for
IHC
is
about
30
months
,
and
for
PHC
about
38
months
.
The
majority
of
patients
with
biliary
malignancies
develop
a
recurrence
after
resection
.
Patients
with
GBC
recur
early
with
a
median
time
to
recurrence
of
12
months
,
versus
about
20
months
for
IHC
and
PHC
.
In
patients
with
resected
IHC
or
PHC
locoregional
recurrence
was
the
only
site
of
recurrence
in
about
60
%
of
patients
,
versus
15
%
in
patients
with
GBC
.
Poor
prognostic
factors
after
resection
of
all
biliary
malignancies
include
the
presence
of
lymph
node
metastasis
,
a
positive
surgical
resection
margin
,
and
moderate
or
poor
tumor
differentiation
.
Several
prognostic
nomograms
have
been
developed
to
predict
long
-term
outcomes
of
biliary
cancer
resection
.
Diseases
Validation
Diseases presenting
"biliary cancer resection"
symptom
cholangiocarcinoma
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