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Risk factors for combined hepatocellular-cholangiocarcinoma: a hospital-based case-control study.
[cholangiocarcinoma]
To
identify
risk
factors
contributing
to
the
development
of
combined
hepatocellular-
cholangiocarcinoma
(
CHC
)
in
China
.
One
hundred
and
twenty-
six
patients
with
CHC
and
4
:
1
matched
healthy
controls
were
interviewed
during
the
period
from
February
2000
to
October
2012
.
Logistic
regression
analysis
was
used
to
calculate
odds
ratios
(
OR
)
and
95
%
confidence
intervals
(
CI
)
for
each
risk
factor
.
Univariate
analysis
showed
that
the
significant
risk
factors
for
CHC
development
were
hepatitis
B
virus
(
HBV
)
infection
,
heavy
alcohol
consumption
,
a
family
history
of
liver
cancer
,
and
diabetes
mellitus
.
Multivariate
stepwise
logistic
regression
analysis
showed
that
HBV
infection
(
OR
=
19
.
245
,
95
%
CI
:
13
.
260
-
27
.
931
)
and
heavy
alcohol
consumption
(
OR
=
2
.
186
,
95
%
CI
:
1
.
070
-
4
.
466
)
were
independent
factors
contributing
to
the
development
of
CHC
.
HBV
infection
and
heavy
alcohol
consumption
may
play
a
role
in
the
development
of
CHC
in
China
.
