Long-term outcome after surgical resection for cholangiocarcinoma and prognostic index value.

[cholangiocarcinoma]

To investigate the prognostic factors of patients with cholangiocarcinoma and establish a prognostic model to evaluate the prognosis .169 cases of cholangiocarcinoma were analyzed retrospectively . Clinicopathological factors were evaluated using univariate and multivariate analysis . Prognostic index (PI ) was calculated based on the results of multivariate analysis . Patients with different PI were divided into 3 groups in order to compare the survival rate of each group and draw the survival curves . Individual expected survival rate was calculated based on the prognostic Cox model and PI . The PI equation was built that included all significant variables and coefficients as follow formula : PI = (β 1 × lymph node metastasis ) + (β 2 × CEA level ) - (β 3 × surgical margin ).Univariate analysis showed that CEA , lymph node metastasis , surgical margin , AJCC staging , tumor differentiation and adjuvant chemotherapy were prognostic impacts . The difference was statistically significant (p < 0 .05 ). Cox multivariate analysis showed that CEA , lymph node metastasis and surgical margin are three separate prognostic factors . According to different PI , patients were divided into high -risk group , middle -risk group and low -risk group and three groups were statistically significant difference in survival rate (P < 0 .05 ).Racical resection is the key to improve the long -term survival rate of cholangiocarcinoma . By using prognostic Cox model and the PI , the prognosis of patients could be estimated and individualized clinical treatment could be conducted .