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EZH2 elevates the proliferation of human cholangiocarcinoma cells through the downregulation of RUNX3.
[cholangiocarcinoma]
To
investigate
the
impact
of
histone
methyltransferase
enhancer
of
zeste
homolog
2
(
EZH
2
)
on
the
proliferation
and
apoptosis
of
human
cholangiocarcinoma
cells
as
well
as
its
related
mechanisms
.
Immunohistochemistry
and
Western
blot
analyses
were
used
to
examine
the
expression
of
EZH
2
in
40
cases
of
human
cholangiocarcinoma
tissues
and
four
strains
of
human
cholangiocarcinoma
cells
.
The
influence
of
EZH
2
on
cell
growth
and
apoptosis
were
assessed
by
knockdown
experiments
,
and
a
xenograft
experiment
in
nude
mice
was
performed
to
evaluate
the
impact
of
siEZH
2
on
the
tumorigenicity
of
tumor
cells
.
The
correlation
of
EZH
2
,
clinic
pathological
features
and
overall
survival
rates
was
also
analyzed
.
EZH
2
was
highly
expressed
in
human
cholangiocarcinoma
tissues
and
cells
.
Silencing
of
EZH
2
could
significantly
reduce
the
methylation
level
of
RUNX
3
DNA
in
human
cholangiocarcinoma
cells
and
improve
its
protein
expression
as
well
as
inhibit
cell
proliferation
,
induce
apoptosis
and
slow
down
the
growth
of
tumor
in
nude
mice
.
In
addition
,
the
expression
of
EZH
2
was
associated
with
the
tumor
stage
,
lymph
node
positivity
and
poor
prognoses
.
Overexpression
of
EZH
2
can
promote
the
proliferation
of
cholangiocarcinoma
cells
and
inhibit
their
apoptosis
.
It
is
associated
with
poor
prognoses
in
patients
with
cholangiocarcinoma
.
Therefore
,
EZH
2
could
be
a
potential
clinical
therapeutic
target
for
the
treatment
of
cholangiocarcinoma
.
