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Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini.
[cholangiocarcinoma]
The
snail
Bithynia
siamensis
goniomphalos
acts
as
the
first
intermediate
host
for
the
human
liver
fluke
Opisthorchis
viverrini
,
the
major
cause
of
cholangiocarcinoma
(
CCA
)
in
Northeast
Thailand
.
The
undisputed
link
between
CCA
and
O
.
viverrini
infection
has
precipitated
efforts
to
understand
the
molecular
basis
of
host-parasite
interactions
with
a
view
to
ultimately
developing
new
control
strategies
to
combat
this
carcinogenic
infection
.
To
date
most
effort
has
focused
on
the
interactions
between
the
parasite
and
its
human
host
,
and
little
is
known
about
the
molecular
relationships
between
the
liver
fluke
and
its
snail
intermediate
host
.
In
the
present
study
we
analyse
the
protein
expression
changes
in
different
tissues
of
B
.
siamensis
goniomphalos
induced
by
infection
with
larval
O
.
viverrini
using
iTRAQ
labelling
technology
.
We
show
that
O
.
viverrini
infection
downregulates
the
expression
of
oxidoreductases
and
catalytic
enzymes
,
while
stress-related
and
motor
proteins
are
upregulated
.
The
present
work
could
serve
as
a
basis
for
future
studies
on
the
proteins
implicated
in
the
susceptibility
/
resistance
of
B
.
siamensis
goniomphalos
to
O
.
viverrini
,
as
well
as
studies
on
other
pulmonate
snail
intermediate
hosts
of
various
parasitic
flukes
that
infect
humans
.
Despite
the
importance
and
high
prevalence
of
opisthorchiasis
in
some
regions
of
Southeast
Asia
and
the
direct
relationship
between
infection
by
Opisthorchis
viverrini
and
the
incidence
of
cholangiocarcinoma
,
little
is
known
of
the
modifications
induced
by
this
parasite
in
its
snail
intermediate
hosts
.
This
time-course
study
provides
the
first
in
-depth
quantitative
proteomic
analysis
of
experimentally
infected
Bithynia
siamensis
goniomphalos
.
We
show
how
motor
and
stress-related
proteins
are
upregulated
in
infected
snails
,
while
O
.
viverrini
infection
downregulates
the
expression
of
oxidoreductases
and
catalytic
enzymes
.
This
work
serves
as
a
basis
for
the
development
of
new
strategies
,
focused
on
the
invertebrate
intermediate
hosts
,
to
control
parasite
transmission
.
Diseases
Validation
Diseases presenting
"first intermediate host for the human liver fluke"
symptom
cholangiocarcinoma
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