Rare Diseases Symptoms Automatic Extraction
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[Risk factors of hepatolithasis-associated intrahepatic cholangiocarcinoma and the value of serum tumor-related makers in its diagnosis].
[cholangiocarcinoma]
To
explore
the
risk
factors
of
hepatolithasis-associated
intrahepatic
cholangiocarcinoma
(
HICC
)
and
the
clinical
value
of
serum
tumor
-related
markers
for
the
detection
of
HICC
.
Clinical
data
were
collected
from
58
patients
pathologically
diagnosed
as
HICC
between
2005
and
2011
in
West
China
Hospital
of
Sichuan
University
and
189
patients
diagnosed
as
hepatolithiasis
alone
in
the
same
period
as
matched
control
group
.
Logistic
regression
analysis
was
used
to
detect
the
independent
risk
factors
of
HICC
and
ROCs
curve
were
constructed
to
assess
the
diagnostic
value
of
CA
1
99
,
CEA
,
GGT
and
ALP
.
T
he
patients
in
both
HICC
group
and
control
group
presented
similar
clinical
symptoms
except
weight
loss
.
The
results
of
univariate
analysis
suggested
cholangioenterostomy
(
P
<
0
.
001
)
,
early
stone
removal
(
OR
=
0
.
001
)
,
family
history
of
cancer
(
P
=
0
.
001
)
were
associated
with
the
incidence
of
HICC
.
The
results
of
Multivariate
analysis
suggested
diabetes
mellitus
(
OR
=
3
.
621
,
95
%
CI
:
1
.
333
-
9
.
834
,
P
=
0
.
012
)
,
family
history
of
cancer
(
OR
=
16
.
830
,
95
%
CI
:
1
.
937
-
146
.
21
,
P
=
0
.
010
)
,
cholangioenterostomy
(
OR
=
5
.
115
,
95
%
CI
:
1
.
733
-
15
.
098
,
P
=
0
.
003
)
,
early
removal
of
stone
(
OR
=
0
.
315
,
95
%
CI
:
0
.
128
-
0
.
771
,
P
=
0
.
011
)
and
CA
1
99
>
100
IU
/
mL
(
OR
=
5
.
478
,
95
%
CI
:
2
.
539
-
11
.
820
,
P
<
0
.
001
)
were
independent
risk
factors
for
hICC
.
Serum
CA
1
99
and
CEA
level
presented
low
diagnostic
accuracy
,
a
combined
test
(
CA
1
99
>
100
IU
/
mL
or
CEA
>
5
ng
/
mL
)
showed
better
diagnostic
performance
with
a
71
.
05
%
of
sensitivity
and
82
.
05
%
of
specificity
.
Cholangioenterostomy
,
diabetes
,
early
and
complete
stone
removal
were
independent
risk
factors
for
hepatolithiasis-associated
ICC
.
A
combined
test
of
CA
1
99
and
CEA
could
be
an
effective
detecting
tool
for
HICC
.
Diseases
Validation
Diseases presenting
"diabetes mellitus"
symptom
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
alpha-thalassemia
child syndrome
cholangiocarcinoma
cohen syndrome
congenital adrenal hyperplasia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cystinuria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
malignant atrophic papulosis
neuralgic amyotrophy
pyomyositis
sneddon syndrome
typhoid
werner syndrome
wolf-hirschhorn syndrome
This symptom has already been validated