Rare Diseases Symptoms Automatic Extraction
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[Risk factors of hepatolithasis-associated intrahepatic cholangiocarcinoma and the value of serum tumor-related makers in its diagnosis].
[cholangiocarcinoma]
To
explore
the
risk
factors
of
hepatolithasis-associated
intrahepatic
cholangiocarcinoma
(
HICC
)
and
the
clinical
value
of
serum
tumor
-related
markers
for
the
detection
of
HICC
.
Clinical
data
were
collected
from
58
patients
pathologically
diagnosed
as
HICC
between
2005
and
2011
in
West
China
Hospital
of
Sichuan
University
and
189
patients
diagnosed
as
hepatolithiasis
alone
in
the
same
period
as
matched
control
group
.
Logistic
regression
analysis
was
used
to
detect
the
independent
risk
factors
of
HICC
and
ROCs
curve
were
constructed
to
assess
the
diagnostic
value
of
CA
1
99
,
CEA
,
GGT
and
ALP
.
T
he
patients
in
both
HICC
group
and
control
group
presented
similar
clinical
symptoms
except
weight
loss
.
The
results
of
univariate
analysis
suggested
cholangioenterostomy
(
P
<
0
.
001
)
,
early
stone
removal
(
OR
=
0
.
001
)
,
family
history
of
cancer
(
P
=
0
.
001
)
were
associated
with
the
incidence
of
HICC
.
The
results
of
Multivariate
analysis
suggested
diabetes
mellitus
(
OR
=
3
.
621
,
95
%
CI
:
1
.
333
-
9
.
834
,
P
=
0
.
012
)
,
family
history
of
cancer
(
OR
=
16
.
830
,
95
%
CI
:
1
.
937
-
146
.
21
,
P
=
0
.
010
)
,
cholangioenterostomy
(
OR
=
5
.
115
,
95
%
CI
:
1
.
733
-
15
.
098
,
P
=
0
.
003
)
,
early
removal
of
stone
(
OR
=
0
.
315
,
95
%
CI
:
0
.
128
-
0
.
771
,
P
=
0
.
011
)
and
CA
1
99
>
100
IU
/
mL
(
OR
=
5
.
478
,
95
%
CI
:
2
.
539
-
11
.
820
,
P
<
0
.
001
)
were
independent
risk
factors
for
hICC
.
Serum
CA
1
99
and
CEA
level
presented
low
diagnostic
accuracy
,
a
combined
test
(
CA
1
99
>
100
IU
/
mL
or
CEA
>
5
ng
/
mL
)
showed
better
diagnostic
performance
with
a
71
.
05
%
of
sensitivity
and
82
.
05
%
of
specificity
.
Cholangioenterostomy
,
diabetes
,
early
and
complete
stone
removal
were
independent
risk
factors
for
hepatolithiasis-associated
ICC
.
A
combined
test
of
CA
1
99
and
CEA
could
be
an
effective
detecting
tool
for
HICC
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated