Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Risk factors of hepatolithasis-associated intrahepatic cholangiocarcinoma and the value of serum tumor-related makers in its diagnosis].
[cholangiocarcinoma]
To
explore
the
risk
factors
of
hepatolithasis-associated
intrahepatic
cholangiocarcinoma
(
HICC
)
and
the
clinical
value
of
serum
tumor
-related
markers
for
the
detection
of
HICC
.
Clinical
data
were
collected
from
58
patients
pathologically
diagnosed
as
HICC
between
2005
and
2011
in
West
China
Hospital
of
Sichuan
University
and
189
patients
diagnosed
as
hepatolithiasis
alone
in
the
same
period
as
matched
control
group
.
Logistic
regression
analysis
was
used
to
detect
the
independent
risk
factors
of
HICC
and
ROCs
curve
were
constructed
to
assess
the
diagnostic
value
of
CA
1
99
,
CEA
,
GGT
and
ALP
.
T
he
patients
in
both
HICC
group
and
control
group
presented
similar
clinical
symptoms
except
weight
loss
.
The
results
of
univariate
analysis
suggested
cholangioenterostomy
(
P
<
0
.
001
)
,
early
stone
removal
(
OR
=
0
.
001
)
,
family
history
of
cancer
(
P
=
0
.
001
)
were
associated
with
the
incidence
of
HICC
.
The
results
of
Multivariate
analysis
suggested
diabetes
mellitus
(
OR
=
3
.
621
,
95
%
CI
:
1
.
333
-
9
.
834
,
P
=
0
.
012
)
,
family
history
of
cancer
(
OR
=
16
.
830
,
95
%
CI
:
1
.
937
-
146
.
21
,
P
=
0
.
010
)
,
cholangioenterostomy
(
OR
=
5
.
115
,
95
%
CI
:
1
.
733
-
15
.
098
,
P
=
0
.
003
)
,
early
removal
of
stone
(
OR
=
0
.
315
,
95
%
CI
:
0
.
128
-
0
.
771
,
P
=
0
.
011
)
and
CA
1
99
>
100
IU
/
mL
(
OR
=
5
.
478
,
95
%
CI
:
2
.
539
-
11
.
820
,
P
<
0
.
001
)
were
independent
risk
factors
for
hICC
.
Serum
CA
1
99
and
CEA
level
presented
low
diagnostic
accuracy
,
a
combined
test
(
CA
1
99
>
100
IU
/
mL
or
CEA
>
5
ng
/
mL
)
showed
better
diagnostic
performance
with
a
71
.
05
%
of
sensitivity
and
82
.
05
%
of
specificity
.
Cholangioenterostomy
,
diabetes
,
early
and
complete
stone
removal
were
independent
risk
factors
for
hepatolithiasis-associated
ICC
.
A
combined
test
of
CA
1
99
and
CEA
could
be
an
effective
detecting
tool
for
HICC
.
Diseases
Validation
Diseases presenting
"weight loss"
symptom
allergic bronchopulmonary aspergillosis
benign recurrent intrahepatic cholestasis
carcinoma of the gallbladder
cholangiocarcinoma
cutaneous mastocytosis
dedifferentiated liposarcoma
dentinogenesis imperfecta
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
focal myositis
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
krabbe disease
oligodontia
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
von hippel-lindau disease
werner syndrome
This symptom has already been validated
