Rare Diseases Symptoms Automatic Extraction

Salvage Radiation Therapy for Isolated Local Recurrence of Extrahepatic Cholangiocarcinoma After Radical Surgery: A Retrospective Study.

[cholangiocarcinoma]

This study investigated the outcomes of salvage radiation therapy (RT) for isolated local recurrence of extrahepatic cholangiocarcinoma (EHCC) after radical surgery.Between May 2003 and July 2011, 25 patients with isolated recurrence of EHCC received RT with the aim of salvage. The most common primary cancer was common bile duct cancer (n = 15) followed by hilar cholangiocarcinoma (n = 7) and pancreaticobiliary type of ampulla of Vater cancer (n = 3). The median disease-free interval from initial operation to recurrence was 12 months. The criteria for diagnosis of recurrence were based on radiographic findings with either computed tomography or positron emission tomography. The radiation dose ranged from 40 to 54 Gy (median 54 Gy), and concurrent chemotherapy was administered to 19 patients.The median follow-up period was 16 months. Local progression occurred in nine patients (36 %). The 2-year local failure-free survival rate was 44 % during a median follow-up period of 14 months. The 2-year overall survival rate was 55 % during a median follow-up period of 24 months. A normal level of CA 19-9 at recurrence and concurrent chemotherapy were favorable prognostic factors for both local control and overall survival. Distant metastasis developed in 11 patients, and the liver was the most common site (n = 7) of distant metastasis. No severe radiation-induced gastrointestinal toxicities developed.Salvage RT with or without concurrent chemotherapy resulted in a median survival of 24 months for patients with isolated local recurrence of EHCC. The treatment was feasible and safe with minimal toxicities.

Diseases presenting "cancer" symptom

  • achondroplasia
  • acute rheumatic fever
  • adrenal incidentaloma
  • alpha-thalassemia
  • benign recurrent intrahepatic cholestasis
  • cadasil
  • canavan disease
  • carcinoma of the gallbladder
  • cholangiocarcinoma
  • coats disease
  • congenital adrenal hyperplasia
  • congenital diaphragmatic hernia
  • cowden syndrome
  • cushing syndrome
  • cutaneous mastocytosis
  • dedifferentiated liposarcoma
  • dystrophic epidermolysis bullosa
  • epidermolysis bullosa simplex
  • erdheim-chester disease
  • erythropoietic protoporphyria
  • esophageal adenocarcinoma
  • esophageal carcinoma
  • esophageal squamous cell carcinoma
  • familial hypocalciuric hypercalcemia
  • familial mediterranean fever
  • gm1 gangliosidosis
  • heparin-induced thrombocytopenia
  • hereditary cerebral hemorrhage with amyloidosis
  • hirschsprung disease
  • hodgkin lymphoma, classical
  • inclusion body myositis
  • junctional epidermolysis bullosa
  • kabuki syndrome
  • kallmann syndrome
  • kindler syndrome
  • lamellar ichthyosis
  • liposarcoma
  • locked-in syndrome
  • lymphangioleiomyomatosis
  • monosomy 21
  • neuralgic amyotrophy
  • oculocutaneous albinism
  • oligodontia
  • oral submucous fibrosis
  • papillon-lefèvre syndrome
  • pendred syndrome
  • pleomorphic liposarcoma
  • primary effusion lymphoma
  • proteus syndrome
  • pyomyositis
  • pyruvate dehydrogenase deficiency
  • severe combined immunodeficiency
  • sneddon syndrome
  • systemic capillary leak syndrome
  • triple a syndrome
  • von hippel-lindau disease
  • waldenström macroglobulinemia
  • well-differentiated liposarcoma
  • werner syndrome
  • wiskott-aldrich syndrome
  • wolf-hirschhorn syndrome
  • x-linked adrenoleukodystrophy

This symptom has already been validated