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Salvage Radiation Therapy for Isolated Local Recurrence of Extrahepatic Cholangiocarcinoma After Radical Surgery: A Retrospective Study.
[cholangiocarcinoma]
This
study
investigated
the
outcomes
of
salvage
radiation
therapy
(
RT
)
for
isolated
local
recurrence
of
extrahepatic
cholangiocarcinoma
(
EHCC
)
after
radical
surgery
.
Between
May
2003
and
July
2011
,
25
patients
with
isolated
recurrence
of
EHCC
received
RT
with
the
aim
of
salvage
.
The
most
common
primary
cancer
was
common
bile
duct
cancer
(
n
=
15
)
followed
by
hilar
cholangiocarcinoma
(
n
=
7
)
and
pancreaticobiliary
type
of
ampulla
of
Vater
cancer
(
n
=
3
)
.
The
median
disease-free
interval
from
initial
operation
to
recurrence
was
12
months
.
The
criteria
for
diagnosis
of
recurrence
were
based
on
radiographic
findings
with
either
computed
tomography
or
positron
emission
tomography
.
The
radiation
dose
ranged
from
40
to
54
Gy
(
median
54
Gy
)
,
and
concurrent
chemotherapy
was
administered
to
19
patients
.
The
median
follow-up
period
was
16
months
.
Local
progression
occurred
in
nine
patients
(
36
%
)
.
The
2
-
year
local
failure
-free
survival
rate
was
44
%
during
a
median
follow-up
period
of
14
months
.
The
2
-
year
overall
survival
rate
was
55
%
during
a
median
follow-up
period
of
24
months
.
A
normal
level
of
CA
19
-
9
at
recurrence
and
concurrent
chemotherapy
were
favorable
prognostic
factors
for
both
local
control
and
overall
survival
.
Distant
metastasis
developed
in
11
patients
,
and
the
liver
was
the
most
common
site
(
n
=
7
)
of
distant
metastasis
.
No
severe
radiation-induced
gastrointestinal
toxicities
developed
.
Salvage
RT
with
or
without
concurrent
chemotherapy
resulted
in
a
median
survival
of
24
months
for
patients
with
isolated
local
recurrence
of
EHCC
.
The
treatment
was
feasible
and
safe
with
minimal
toxicities
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
