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Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma.
[cholangiocarcinoma]
Obstructive
jaundice
caused
by
metastases
to
the
porta
hepatis
is
often
observed
in
patients
with
various
advanced
cancers
;
however
,
metastasis
of
lung
cancer
to
the
common
bile
duct
with
subsequent
development
of
jaundice
is
rare
.
A
75
-
year
-old
female
with
lung
adenocarcinoma
harboring
epidermal
growth
factor
receptor
(
EGFR
)
mutation
(
15
-
bp
in
-frame
deletion
in
exon
19
and
T
790
M
in
exon
20
)
developed
obstructive
jaundice
during
therapy
.
Obstruction
of
the
common
bile
duct
caused
by
an
intraductal
tumor
was
identified
by
computed
tomography
,
endoscopic
retrograde
cholangiopancreatography
,
and
endoscopic
ultrasonography
.
Although
primary
cholangiocarcinoma
was
highly
suspected
according
to
the
imaging
findings
,
immunohistochemical
evaluation
of
the
intraductal
tumor
demonstrated
thyroid
transcription
factor
-
1
positive
adenocarcinoma
.
Furthermore
,
peptide
nucleic
acid-locked
nucleic
acid
polymerase
chain
reaction
clamp
analysis
showed
that
the
tumor
contained
the
same
EGFR
mutation
as
that
in
the
primary
lung
cancer
.
Thus
,
we
confirmed
intraductal
metastasis
from
a
lung
adenocarcinoma
.
To
our
knowledge
,
this
is
the
second
report
of
obstructive
jaundice
caused
by
intraductal
metastasis
of
lung
cancer
.
Diseases
Validation
Diseases presenting
"developed obstructive jaundice during therapy"
symptom
cholangiocarcinoma
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