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Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma.
[cholangiocarcinoma]
Obstructive
jaundice
caused
by
metastases
to
the
porta
hepatis
is
often
observed
in
patients
with
various
advanced
cancers
;
however
,
metastasis
of
lung
cancer
to
the
common
bile
duct
with
subsequent
development
of
jaundice
is
rare
.
A
75
-
year
-old
female
with
lung
adenocarcinoma
harboring
epidermal
growth
factor
receptor
(
EGFR
)
mutation
(
15
-
bp
in
-frame
deletion
in
exon
19
and
T
790
M
in
exon
20
)
developed
obstructive
jaundice
during
therapy
.
Obstruction
of
the
common
bile
duct
caused
by
an
intraductal
tumor
was
identified
by
computed
tomography
,
endoscopic
retrograde
cholangiopancreatography
,
and
endoscopic
ultrasonography
.
Although
primary
cholangiocarcinoma
was
highly
suspected
according
to
the
imaging
findings
,
immunohistochemical
evaluation
of
the
intraductal
tumor
demonstrated
thyroid
transcription
factor
-
1
positive
adenocarcinoma
.
Furthermore
,
peptide
nucleic
acid-locked
nucleic
acid
polymerase
chain
reaction
clamp
analysis
showed
that
the
tumor
contained
the
same
EGFR
mutation
as
that
in
the
primary
lung
cancer
.
Thus
,
we
confirmed
intraductal
metastasis
from
a
lung
adenocarcinoma
.
To
our
knowledge
,
this
is
the
second
report
of
obstructive
jaundice
caused
by
intraductal
metastasis
of
lung
cancer
.
Diseases
Validation
Diseases presenting
"lung cancer"
symptom
adrenal incidentaloma
cholangiocarcinoma
cushing syndrome
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
kindler syndrome
liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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