Rare Diseases Symptoms Automatic Extraction
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[The value of CA19-9 and CEA in predicting resectability of hilar cholangiocarcinoma].
[cholangiocarcinoma]
To
evaluate
the
predictability
of
preoperative
serum
Carbonhydrate
antigen
(
CA
1
9
-
9
)
and
Carcino-embryonic
antigen
(
CEA
)
for
tumor
resectability
in
the
patients
with
hilar
cholangiocarcinoma
(
HC
)
.
One
hundred
and
three
HC
patients
pathologically
diagnosed
from
2003
to
2012
were
divided
into
radical
resection
group
and
palliative
treatment
group
according
to
their
surgical
therapy
and
resection
results
,
and
preoperative
serum
CA
1
9
-
9
and
CEA
data
was
collected
and
analyzed
retrospectively
.
Receiver
operating
characteristic
(
ROC
)
curve
analysis
was
applied
to
find
the
best
cut-off
point
,
and
the
resectability
prediction
of
different
detection
methods
was
evaluated
.
In
the
application
of
ROC
analysis
,
the
cut-off
point
of
CA
1
9
-
9
and
CEA
were
400
microg
/
L
and
8
microg
/
L
with
the
largest
Youden
's
index
0
.
2345
(
AUC
=
0
.
605
+
/
-
0
.
057
)
and
0
.
1635
(
AUC
=
0
.
631
+
/
-
0
.
055
)
respectively
.
The
ROC-AUC
,
sensitivity
,
specificity
,
negative
predictive
value
and
positive
predictive
value
in
the
combine
detection
(
parallel
test
)
with
this
new
cut-off
point
were
0
.
660
+
/
-
0
.
054
,
62
.
79
%
,
65
.
00
%
,
56
.
25
%
and
83
.
33
%
respectively
.
The
HC
patients
with
"
CA
1
9
-
9
<
400
microg
/
L
+
CEA
<
8
microg
/
L
"
may
have
big
opportunity
to
have
radical
resection
while
those
with
"
CA
1
9
-
9
>
or
=
400
microg
/
L
or
CEA
>
or
=
8
microg
/
L
"
may
have
small
opportunity
.
