Overexpression of Sig1R is closely associated with tumor progression and poor outcome in patients with hilar cholangiocarcinoma.

[cholangiocarcinoma]

Nonopioid Sigma 1 receptor (Sig 1 R ), which regulates various metabolism functions , has been implicated in cancers ; yet , its role in hilar cholangiocarcinoma remains unclear . In the present study , we examined Sig 1 R expression in hilar cholangiocarcinoma (HC ) tissues and explored its possible clinical values . Tissue microarray blocks containing 92 HC tissues and matched non-cancerous bile duct tissues were examined immunohistochemically for expression of Sig 1 R protein . Overexpression of Sig 1 R was found in 43 (46 .7 Â %) of the 92 primary tumor tissues . Overexpression of Sig 1 R was significantly associated with poor /undifferentiation (P Â =Â 0 .011 ), tumor invasion (P Â =Â 0 .001 ), lymph node metastasis (P Â =Â 0 .047 ), and advanced disease stage (P Â =Â 0 .024 ) of HC patients . Kaplan-Meier analysis showed that patients overexpressing Sig 1 R had an earlier recurrence and worse overall survival than those not overexpressing Sig 1 R . Cox regression analysis revealed that Sig 1 R was an independent factor to predict HC recurrence and prognosis of HC patients . Our results suggest that Sig 1 R is frequently activated in human HC tissue and overexpression of Sig 1 R might serve as a predictor for tumor recurrence and a prognostic biomarker for HC patients .

Diseases
Validation

Diseases presenting "poor/undifferentiation" symptom

cholangiocarcinoma

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