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Overexpression of Sig1R is closely associated with tumor progression and poor outcome in patients with hilar cholangiocarcinoma.
[cholangiocarcinoma]
Nonopioid
Sigma
1
receptor
(
Sig
1
R
)
,
which
regulates
various
metabolism
functions
,
has
been
implicated
in
cancers
;
yet
,
its
role
in
hilar
cholangiocarcinoma
remains
unclear
.
In
the
present
study
,
we
examined
Sig
1
R
expression
in
hilar
cholangiocarcinoma
(
HC
)
tissues
and
explored
its
possible
clinical
values
.
Tissue
microarray
blocks
containing
92
HC
tissues
and
matched
non-cancerous
bile
duct
tissues
were
examined
immunohistochemically
for
expression
of
Sig
1
R
protein
.
Overexpression
of
Sig
1
R
was
found
in
43
(
46
.
7
%
)
of
the
92
primary
tumor
tissues
.
Overexpression
of
Sig
1
R
was
significantly
associated
with
poor
/
undifferentiation
(
P
=
0
.
011
)
,
tumor
invasion
(
P
=
0
.
001
)
,
lymph
node
metastasis
(
P
=
0
.
047
)
,
and
advanced
disease
stage
(
P
=
0
.
024
)
of
HC
patients
.
Kaplan-
Meier
analysis
showed
that
patients
overexpressing
Sig
1
R
had
an
earlier
recurrence
and
worse
overall
survival
than
those
not
overexpressing
Sig
1
R
.
Cox
regression
analysis
revealed
that
Sig
1
R
was
an
independent
factor
to
predict
HC
recurrence
and
prognosis
of
HC
patients
.
Our
results
suggest
that
Sig
1
R
is
frequently
activated
in
human
HC
tissue
and
overexpression
of
Sig
1
R
might
serve
as
a
predictor
for
tumor
recurrence
and
a
prognostic
biomarker
for
HC
patients
.
