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Hilar cholangiocarcinoma: Controversies on the extent of surgical resection aiming at cure.
[cholangiocarcinoma]
Hilar
cholangiocarcinoma
is
the
most
common
malignant
tumor
affecting
the
extrahepatic
bile
duct
.
Surgical
treatment
offers
the
only
possibility
of
cure
,
and
it
requires
removal
of
all
tumoral
tissues
with
adequate
resection
margins
.
The
aims
of
this
review
are
to
summarize
the
findings
and
to
discuss
the
controversies
on
the
extent
of
surgical
resection
aiming
at
cure
for
hilar
cholangiocarcinoma
.
The
English
medical
literatures
on
hilar
cholangiocarcinoma
were
studied
to
review
on
the
relevance
of
adequate
resection
margins
,
routine
caudate
lobe
resection
,
extent
of
liver
resection
,
and
combined
vascular
resection
on
perioperative
and
long
-term
survival
outcomes
of
patients
with
resectable
hilar
cholangiocarcinoma
.
Complete
resection
of
tumor
represents
the
most
important
prognostic
factor
of
long
-term
survival
for
hilar
cholangiocarcinoma
.
The
primary
aim
of
surgery
is
to
achieve
R
0
resection
.
When
R
1
resection
is
shown
intraoperatively
,
further
resection
is
recommended
.
Combined
hepatic
resection
is
now
generally
accepted
as
a
standard
procedure
even
for
Bismuth
type
I
/
II
tumors
.
Routine
caudate
lobe
resection
is
also
advocated
for
cure
.
The
extent
of
hepatic
resection
remains
controversial
.
Most
surgeons
recommend
major
hepatic
resection
.
However
,
minor
hepatic
resection
has
also
been
advocated
in
most
patients
.
The
decision
to
carry
out
right
-
or
left-sided
hepatectomy
is
made
according
to
the
predominant
site
of
the
lesion
.
Portal
vein
resection
should
be
considered
when
its
involvement
by
tumor
is
suspected
.
The
curative
treatment
of
hilar
cholangiocarcinoma
remains
challenging
.
Advances
in
hepatobiliary
techniques
have
improved
the
perioperative
and
long
-term
survival
outcomes
of
this
tumor
.
Diseases
Validation
Diseases presenting
"factor of long-term survival for hilar cholangiocarcinoma"
symptom
cholangiocarcinoma
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