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Synchronous double cancers of primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma: a case report and review of the literature.
[cholangiocarcinoma]
We
report
a
case
of
double
primary
liver
cancer
comprising
hepatocellular
carcinoma
(
HCC
)
and
intrahepatic
cholangiocarcinoma
(
ICC
)
.
A
58
-
year
-old
Chinese
man
without
obvious
liver
cirrhosis
was
diagnosed
with
multiple
HCC
in
segment
V
(
SV
)
and
segment
VIII
(
SVIII
)
of
the
liver
.
Preoperative
abdominal
magnetic
resonance
imaging
revealed
two
solid
masses
in
SV
and
SVIII
.
We
performed
hepatic
resection
of
both
segments
.
The
tumors
in
SV
and
SVIII
were
pathologically
diagnosed
as
HCC
and
ICC
,
respectively
.
Immunohistochemically
,
the
HCC
in
SV
was
positive
for
carcinoembryonic
antigen
and
negative
for
α-fetoprotein
(
AFP
)
and
cytokeratin
(
CK
)
,
while
the
ICC
in
SVIII
was
negative
for
both
AFP
and
CK
.
These
observations
confirmed
the
diagnosis
of
double
primary
liver
cancer
(
HCC
and
ICC
)
.
Double
primary
liver
cancer
is
extremely
rare
.
We
herein
review
previous
reports
of
patients
with
a
histological
diagnosis
of
double
primary
liver
cancer
.
Based
on
the
findings
of
this
case
and
the
literature
review
,
we
speculate
that
the
imaging
findings
of
double
primary
hepatic
cancer
conform
to
the
pathologic
findings
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated