Is child intelligence associated with parent and sibling intelligence in individuals with developmental disorders? An investigation in youth with 22q11.2 deletion (velo-cardio-facial) syndrome.

[22q11.2 deletion syndrome]

Children with 22 q 11 .2 deletion syndrome (22 q 11 DS ), a copy-number variation (CNV ) genetic disorder , demonstrate a great deal of variability in IQ scores and are at particular risk for cognitive difficulties , with up to 45 % experiencing intellectual disability . This study explored the IQ relationship between individuals with 22 q 11 DS , their parents and their siblings . Participants included individuals with 22 q 11 DS , unaffected siblings and community controls , who participated in a longitudinal study of 22 q 11 DS . Significant associations between proband and relative (parent , sibling ) IQ scores were found . Results suggest that the cognitive functioning of first -degree relatives could be a useful marker of general genetic background and /or environmental effects , and can explain some of the large phenotypic variability in 22 q 11 DS . These findings underscore the importance of including siblings and parents in studies of 22 q 11 DS whenever possible .

Diseases
Validation

Diseases presenting "intellectual disability" symptom

22q11.2 deletion syndrome

alexander disease

alpha-thalassemia

aniridia

child syndrome

cohen syndrome

cowden syndrome

hirschsprung disease

homocystinuria without methylmalonic aciduria

hydrocephalus with stenosis of the aqueduct of sylvius

kabuki syndrome

kallmann syndrome

monosomy 21

oculocutaneous albinism

oligodontia

phenylketonuria

proteus syndrome

triple a syndrome

wolf-hirschhorn syndrome

This symptom has already been validated