Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Airway malacia in children with achondroplasia.
[achondroplasia]
This
study
was
undertaken
to
assess
the
frequency
of
airway
malacia
in
infants
and
young
children
with
achondroplasia
,
a
population
well
known
to
be
at
risk
for
a
variety
of
respiratory
problems
.
We
also
wished
to
evaluate
what
,
if
any
,
contribution
airway
malacia
makes
to
the
complex
respiratory
issues
that
may
be
present
in
those
with
achondroplasia
.
Retrospective
chart
review
of
all
infants
and
young
children
with
achondroplasia
who
were
assessed
through
the
Midwest
Regional
Bone
Dysplasia
Clinics
from
1985
through
2012
(
n
 
=
 
236
)
was
completed
.
Records
of
comprehensive
clinical
examinations
,
polysomnographic
assessments
,
and
airway
visualization
were
reviewed
and
abstracted
using
a
data
collection
form
.
Analyses
were
completed
comparing
the
group
with
and
those
without
evidence
for
airway
malacia
.
Thirteen
of
236
patients
(
5
.
5
%
)
were
found
to
have
airway
malacia
.
Most
of
those
affected
had
lower
airway
involvement
(
9
/
13
)
.
The
presence
of
airway
malacia
was
correlated
with
an
increased
occurrence
of
obstructive
sleep
apnea
as
well
as
need
for
oxygen
supplementation
,
airway
surgeries
and
tracheostomy
placement
.
Although
estimates
of
the
frequency
of
airway
malacia
in
the
general
population
are
limited
,
its
frequency
in
children
with
achondroplasia
appears
to
be
much
higher
than
any
published
general
population
estimate
.
The
presence
of
airway
malacia
appears
to
confound
other
breathing
abnormalities
in
this
population
and
results
in
the
need
for
more
invasive
airway
treatments
.
