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Donor dominance cures CHILD nevus.
[child syndrome]
Congenital
hemidysplasia
with
ichthyosiform
nevus
and
limb
defects
(
MIM
308050
,
CHILD
)
syndrome
is
an
X-
linked
dominant
,
male-
lethal
,
multisystem
birth
defect
.
Patients
suffer
from
an
inflammatory
nevus
that
covers
large
areas
,
predominantly
of
one
side
of
the
body
,
with
a
sharp
midline
demarcation
.
Treatment
of
CHILD
nevus
is
notoriously
difficult
.
The
aim
of
this
study
was
to
develop
a
novel
surgical
approach
for
this
disorder
.
In
2
patients
,
the
CHILD
nevus
was
dermabraded
,
and
the
area
was
covered
with
split
skin
grafts
obtained
from
a
contralateral
unaffected
donor
region
.
In
a
third
patient
,
papillomatous
,
strawberry-like
lesions
on
fingers
and
toes
were
excised
,
and
the
defects
were
covered
with
full-thickness
grafts
obtained
from
the
unaffected
left
,
gluteal
area
.
Highly
satisfying
functional
and
cosmetic
results
were
documented
during
a
follow-up
period
ranging
from
3
to
8
years
.
The
favorable
outcome
,
superior
to
that
obtained
by
simple
dermabrasion
or
extensive
plastic
surgery
,
can
best
be
explained
by
the
donor
dominance
of
the
grafted
skin
samples
that
carried
,
in
all
or
most
cells
,
the
mutant
X
chromosome
in
an
inactivated
form
.
Diseases
Validation
Diseases presenting
"predominantly of one side of the body"
symptom
child syndrome
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