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Donor dominance cures CHILD nevus.
[child syndrome]
Congenital
hemidysplasia
with
ichthyosiform
nevus
and
limb
defects
(
MIM
308050
,
CHILD
)
syndrome
is
an
X-
linked
dominant
,
male-
lethal
,
multisystem
birth
defect
.
Patients
suffer
from
an
inflammatory
nevus
that
covers
large
areas
,
predominantly
of
one
side
of
the
body
,
with
a
sharp
midline
demarcation
.
Treatment
of
CHILD
nevus
is
notoriously
difficult
.
The
aim
of
this
study
was
to
develop
a
novel
surgical
approach
for
this
disorder
.
In
2
patients
,
the
CHILD
nevus
was
dermabraded
,
and
the
area
was
covered
with
split
skin
grafts
obtained
from
a
contralateral
unaffected
donor
region
.
In
a
third
patient
,
papillomatous
,
strawberry-like
lesions
on
fingers
and
toes
were
excised
,
and
the
defects
were
covered
with
full-thickness
grafts
obtained
from
the
unaffected
left
,
gluteal
area
.
Highly
satisfying
functional
and
cosmetic
results
were
documented
during
a
follow-up
period
ranging
from
3
to
8
years
.
The
favorable
outcome
,
superior
to
that
obtained
by
simple
dermabrasion
or
extensive
plastic
surgery
,
can
best
be
explained
by
the
donor
dominance
of
the
grafted
skin
samples
that
carried
,
in
all
or
most
cells
,
the
mutant
X
chromosome
in
an
inactivated
form
.
Diseases
Validation
Diseases presenting
"nevus"
symptom
child syndrome
cowden syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
gm1 gangliosidosis
kabuki syndrome
lamellar ichthyosis
liposarcoma
malignant atrophic papulosis
oculocutaneous albinism
proteus syndrome
sneddon syndrome
This symptom has already been validated