Rare Diseases Symptoms Automatic Extraction
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Initial predictive factors of outcome in severe non-accidental head trauma in children.
[child syndrome]
The
aim
of
this
study
is
to
evaluate
the
outcome
of
young
children
hospitalized
for
non-accidental
head
trauma
in
our
PICU
,
to
evaluate
PRISM
II
score
in
this
sub-population
of
pediatric
trauma
and
to
identify
factors
that
might
influence
the
short
-term
outcome
.
Files
of
all
children
less
than
2
years
old
with
the
diagnosis
of
non-accidental
head
trauma
over
a
10
-
years
period
were
systematically
reviewed
.
We
collected
data
on
demographic
information
,
medical
history
,
clinical
status
,
and
management
in
the
PICU
.
Three
severity
scores
were
then
calculated
:
PRISM
II
,
Glasgow
Coma
Scale
(
GCS
)
,
and
Pediatric
Trauma
Score
(
PTS
)
.
Prognosis
value
of
qualitative
variables
was
tested
with
a
univariate
procedure
analysis
(
anemia
,
diabetes
insipidus
.
.
.
)
.
Then
,
quantitative
variables
were
tested
with
univariate
procedure
too
(
age
,
weight
,
PRISM
II
,
GCS
,
Platelet
count
,
fibrin
,
prothrombin
time
(
PT
)
.
.
.
)
.
Potential
association
between
variables
and
death
was
tested
using
univariate
procedure
.
Variables
identified
by
univariate
analysis
were
then
analyzed
with
multivariate
analysis
through
a
forward-stepping
logistic
regression
.
Thirty
-
six
children
were
included
.
Mean
age
was
5
.
5
months
(
8
days
-
21
.
5
months
)
.
Mortality
rate
was
27
.
8
%
.
At
admission
,
PTS
,
PRISM
II
,
GCS
,
PT
,
PTT
,
and
diabetes
insipidus
were
significantly
altered
or
more
frequent
in
non
survivors
.
Cutoff
value
for
PRISM
II
at
which
risk
of
mortality
increased
was
17
.
5
(
sensitivity
=
0
.
8
;
specificity
=
0
.
88
)
.
PRISM
II
is
a
reliable
and
easy
performing
tool
for
assessing
the
prognosis
of
non-accidental
cranial
traumatism
in
young
children
.
GCS
and
PTS
,
scores
even
simpler
than
PRISM
II
,
showed
good
accuracy
regarding
survival
prediction
.
Diseases
Validation
Diseases presenting
"anemia"
symptom
22q11.2 deletion syndrome
alpha-thalassemia
canavan disease
child syndrome
coats disease
congenital toxoplasmosis
cowden syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dracunculiasis
erythropoietic protoporphyria
esophageal adenocarcinoma
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
omenn syndrome
scrub typhus
sneddon syndrome
typhoid
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
This symptom has already been validated