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[Frequently ill child syndrome].
[child syndrome]
The
efficacy
of
cycloferon
use
in
the
treatment
of
frequently
ill
children
(
FIC
)
was
estimated
by
the
dynamics
of
the
blood
plasma
proteomic
profile
.
A
group
of
FIC
at
the
age
of
4
to
10
years
were
observed
.
Cycloferon
was
administered
according
to
the
standard
schemes
.
The
results
were
analysed
by
the
computer
programme
complex
,
including
the
anamnesis
,
clinical
symptoms
,
infection
index
,
findings
of
the
electrophoretic
and
mass-spectrometric
analyses
of
the
blood
plasma
before
and
after
the
drug
use
.
The
intensity
indices
of
the
Rho
and
Ras
proteins
,
the
signal
pathways
,
in
the
blood
proteomic
profile
proved
to
be
sensitive
and
specific
parameters
for
estimating
the
regimens
of
the
therapy
and
prophylaxis
of
respiratory
tract
infection
in
FIC
.
The
epidemiologic
efficacy
of
cycloferon
,
as
an
agent
of
nonspecific
immunoprophylaxis
for
FIC
during
seasonal
prevalence
of
respiratory
tract
infection
and
influenza
cases
was
shown
.