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Verruciform xanthoma: a special epidermal nevus.
[child syndrome]
Congenital
hemidysplasia
with
ichthyosiform
nevus
and
limb
defects
(
CHILD
)
syndrome
is
a
rare
X-
linked
hereditary
disorder
.
Presentation
varies
from
ichthyosiform
nevus
to
complete
limb
amelia
.
We
present
a
17
-
year
-old
adolescent
girl
who
presented
with
a
16
-
cm
exophytic
mass
of
the
right
foot
that
had
been
growing
for
7
years
as
well
as
knee
contracture
.
Deformed
nails
with
onychorrhexis
were
noted
bilaterally
.
History
of
multiple
nonlinear
erythematous
skin
lesions
covered
by
dry
waxy
scales
involving
multiple
body
folds
with
sharp
midline
demarcation
was
obtained
.
The
patient
's
family
history
was
negative
for
consanguinity
and
similar
conditions
.
Radiography
showed
right
leg
hypoplasia
and
osteopenia
.
These
findings
fulfill
the
diagnosis
of
CHILD
syndrome
.
Microscopically
,
psoriasiform
epidermal
hyperplasia
with
marked
orthohyper-keratosis
and
neutrophilic
exocytosis
were
noted
.
The
papillary
dermis
was
packed
with
foamy
macrophages
consistent
with
xanthomatous
changes
,
namely
verruciform
xanthoma
.
Verruciform
xanthoma
,
although
rarely
found
in
other
conditions
,
is
a
characteristic
finding
.
Diseases
Validation
Diseases presenting
"osteopenia"
symptom
achondroplasia
aromatase deficiency
benign recurrent intrahepatic cholestasis
child syndrome
coats disease
cutaneous mastocytosis
dentin dysplasia
dentinogenesis imperfecta
erythropoietic protoporphyria
fabry disease
familial hypocalciuric hypercalcemia
This symptom has already been validated