Multiple Verruciform Xanthomas in the Setting of Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects Syndrome.

[child syndrome]

Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD ) syndrome is a rare X-linked dominant disease characterized by peculiar cutaneous presentations and skeletal abnormalities . Verruciform xanthoma (VX )-like histologic changes occasionally occur in CHILD syndrome , but typical VX-like lesions coexisting with CHILD syndrome are rare . In this study we report a rare case of multiple , coexisting VXs on the vulva and left lower limb of an 11 -year -old Chinese girl who also exhibited the typical clinical presentations and limb defects of CHILD syndrome . Histologic and immunohistochemical analyses showed that the lesions were typical VXs .