Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Embryonic left-right separation mechanism allows confinement of mutation-induced phenotypes to one lateral body half of bilaterians.
[child syndrome]
A
fundamental
question
in
developmental
biology
is
how
a
chimeric
animal
such
as
a
bilateral
gynandromorphic
animal
can
have
different
phenotypes
confined
to
different
lateral
body
halves
,
and
how
mutation
-induced
phenotypes
,
such
as
genetic
diseases
,
can
be
confined
to
one
lateral
body
half
in
patients
.
Here
,
I
propose
that
embryos
of
many
,
if
not
all
,
bilaterian
animals
are
divided
into
left
and
right
halves
at
a
very
early
stage
(
which
may
vary
among
different
types
of
animals
)
,
after
which
the
descendants
of
the
left-sided
and
right
-sided
cells
will
almost
exclusively
remain
on
their
original
sides
,
respectively
,
throughout
the
remaining
development
.
This
embryonic
left-
right
separation
mechanism
allows
(
1
)
mutations
and
the
mutation
-induced
phenotypes
to
be
strictly
confined
to
one
lateral
body
half
in
animals
and
humans
;
(
2
)
mothers
with
bilateral
hereditary
primary
breast
cancer
to
transmit
their
disease
to
their
offspring
at
twofold
of
the
rate
compared
to
mothers
with
unilateral
hereditary
breast
cancer
;
and
(
3
)
a
mosaic
embryo
carrying
genetic
or
epigenetic
mutations
to
develop
into
either
an
individual
with
the
mutation
-induced
phenotype
confined
unilaterally
,
or
a
pair
of
twins
displaying
complete
,
partial
,
or
mirror
-image
discordance
for
the
phenotype
.
Further
,
this
left-
right
separation
mechanism
predicts
that
the
two
lateral
halves
of
a
patient
carrying
a
unilateral
genetic
disease
can
each
serve
as
a
case
and
an
internal
control
,
respectively
,
for
genetic
and
epigenetic
comparative
studies
to
identify
the
disease
causations
.
Diseases
Validation
Diseases presenting
"breast cancer"
symptom
acute rheumatic fever
aromatase deficiency
carcinoma of the gallbladder
child syndrome
cowden syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
oral submucous fibrosis
proteus syndrome
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
This symptom has already been validated