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Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus.
[child syndrome]
A
malignant
transformation
is
known
to
occur
in
many
nevi
such
as
a
sebaceous
nevus
or
a
basal
cell
nevus
,
but
a
verrucous
epidermal
nevus
has
only
rarely
been
associated
with
neoplastic
changes
.
Keratoacanthoma
,
multifocal
papillary
apocrine
adenoma
,
multiple
malignant
eccrine
poroma
,
basal
cell
carcinoma
and
cutaneous
squamous
cell
carcinoma
(
CSCC
)
have
all
been
reported
to
develop
from
a
verrucous
epidermal
nevus
.
CSCC
has
also
been
reported
to
arise
from
other
nevoid
lesions
like
a
nevus
comedonicus
,
porokeratosis
,
a
sebaceous
nevus
,
an
oral
sponge
nevus
and
an
ichthyosiform
nevus
with
CHILD
syndrome
.
Here
we
report
a
case
of
progressive
poorly
differentiated
CSCC
arising
from
a
localized
verrucous
epidermal
nevus
,
which
caused
both
spinal
cord
and
brain
metastasis
.
Diseases
Validation
Diseases presenting
"malignant transformation"
symptom
achondroplasia
adrenal incidentaloma
child syndrome
cholangiocarcinoma
cutaneous mastocytosis
epidermolysis bullosa simplex
esophageal adenocarcinoma
liposarcoma
oral submucous fibrosis
severe combined immunodeficiency
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