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Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction.
[carcinoma of the gallbladder]
Herein
is
reported
a
case
of
mucin-producing
carcinoma
of
the
gallbladder
in
a
55
-
year
-old
Japanese
woman
.
Although
the
patient
's
status
and
laboratory
data
initially
suggested
biliary
pancreatitis
due
to
gallstone
,
radiography
and
endoscopy
confirmed
the
presence
of
pancreaticobiliary
maljunction
and
a
gallbladder
tumor
with
excessive
mucin
,
in
which
the
duodenal
papilla
and
the
common
bile
duct
were
impacted
.
Following
surgery
,
the
gallbladder
tumor
was
histopathologically
diagnosed
as
a
mixed
endocrine-exocrine
carcinoma
.
The
carcinoma
predominantly
consisted
of
papillary
,
but
also
contained
some
tubular
adenocarcinomatous
components
.
Additionally
,
small
foci
of
small
cell
and
large
cell
neuroendocrine
carcinomatous
components
were
observed
.
There
was
no
evidence
of
lymph
node
metastasis
,
distant
metastasis
,
or
direct
invasion
outside
the
gallbladder
.
Thus
,
the
final
classification
of
pT
2
N
0
M
0
stage
II
was
given
to
this
lesion
,
according
to
the
Union
Internationale
Contre
le
Cancer
guidelines
.
The
postoperative
course
was
uneventful
,
and
the
carcinoma
had
not
recurred
in
the
absence
of
chemoradiotherapy
for
a
period
of
20
months
.
Mucin-producing
gallbladder
carcinoma
is
a
rare
clinical
condition
that
can
occur
in
patients
with
pancreaticobiliary
maljunction
.
Detailed
investigation
of
this
condition
is
important
to
develop
and
refine
effective
therapeutic
strategies
.
Diseases
Validation
Diseases presenting
"large cell neuroendocrine carcinomatous components were observed"
symptom
carcinoma of the gallbladder
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