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Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction.
[carcinoma of the gallbladder]
Herein
is
reported
a
case
of
mucin-producing
carcinoma
of
the
gallbladder
in
a
55
-
year
-old
Japanese
woman
.
Although
the
patient
's
status
and
laboratory
data
initially
suggested
biliary
pancreatitis
due
to
gallstone
,
radiography
and
endoscopy
confirmed
the
presence
of
pancreaticobiliary
maljunction
and
a
gallbladder
tumor
with
excessive
mucin
,
in
which
the
duodenal
papilla
and
the
common
bile
duct
were
impacted
.
Following
surgery
,
the
gallbladder
tumor
was
histopathologically
diagnosed
as
a
mixed
endocrine-exocrine
carcinoma
.
The
carcinoma
predominantly
consisted
of
papillary
,
but
also
contained
some
tubular
adenocarcinomatous
components
.
Additionally
,
small
foci
of
small
cell
and
large
cell
neuroendocrine
carcinomatous
components
were
observed
.
There
was
no
evidence
of
lymph
node
metastasis
,
distant
metastasis
,
or
direct
invasion
outside
the
gallbladder
.
Thus
,
the
final
classification
of
pT
2
N
0
M
0
stage
II
was
given
to
this
lesion
,
according
to
the
Union
Internationale
Contre
le
Cancer
guidelines
.
The
postoperative
course
was
uneventful
,
and
the
carcinoma
had
not
recurred
in
the
absence
of
chemoradiotherapy
for
a
period
of
20
months
.
Mucin-producing
gallbladder
carcinoma
is
a
rare
clinical
condition
that
can
occur
in
patients
with
pancreaticobiliary
maljunction
.
Detailed
investigation
of
this
condition
is
important
to
develop
and
refine
effective
therapeutic
strategies
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated