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Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder.
[carcinoma of the gallbladder]
A
small
number
of
patients
with
carcinoma
of
the
gallbladder
can
present
with
a
variety
of
paraneoplastic
syndromes
,
including
the
Cushing
syndrome
,
hypercalcemia
,
acanthosis
nigricans
,
bullous
pemphigoid
,
dermatomyositis
,
and
the
Leser-
Trélat
sign
.
We
report
on
what
appears
to
be
the
first
case
of
a
patient
,
a
48
-
year
-old
woman
,
with
anti-
Hu
paraneoplastic
sensory
neuropathy
and
small
cell
carcinoma
of
the
gallbladder
.
The
patient
's
neurologic
symptoms
preceded
the
diagnosis
of
small
cell
carcinoma
by
11
months
.
These
symptoms
improved
after
surgical
removal
of
the
tumor
and
chemotherapy
.
The
small
cell
carcinoma
was
relatively
small
and
was
not
associated
with
gallstones
.
In
spite
of
the
small
size
of
the
tumor
,
it
metastasized
to
a
celiac
lymph
node
and
probably
to
the
liver
.
Anti-
Hu
paraneoplastic
sensory
neuropathy
should
be
added
to
the
list
of
paraneoplastic
syndromes
associated
with
small
cell
carcinoma
of
the
gallbladder
.