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Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma.
[carcinoma of the gallbladder]
We
present
the
case
of
a
62
-
year
-old
Japanese
man
whose
histological
diagnosis
was
adenoendocrine
cell
carcinoma
of
the
gallbladder
at
autopsy
,
but
whose
antemortem
diagnosis
was
squamous
cell
carcinoma
.
The
patient
was
admitted
to
hospital
with
complaints
of
occasional
vomiting
and
abdominal
pain
.
Abdominal
computed
tomography
revealed
a
large
tumor
on
the
gallbladder
involving
the
adjacent
liver
,
colon
,
and
duodenum
,
with
multiple
metastases
in
the
greater
omentum
and
paraportal
lymph
nodes
.
The
serum
level
of
squamous
cell
carcinoma
antigen
(
SCCA
)
was
high
,
whereas
that
of
carbohydrate
antigen
(
CA
)
19
-
9
,
as
well
as
that
of
carcinoembryonic
antigen
(
CEA
)
was
within
the
normal
range
.
Due
to
these
clinical
features
,
we
first
suspected
advanced
squamous
cell
carcinoma
of
the
gallbladder
.
After
two
cycles
of
gemcitabine
monotherapy
,
the
tumor
had
become
enlarged
and
the
regimen
was
changed
to
a
combination
of
docetaxel
and
cisplatin
.
Though
tumor
regression
was
achieved
and
his
serum
SCCA
level
normalized
after
3
months
,
the
patient
rejected
additional
chemotherapy
and
died
8
months
after
the
diagnosis
.
The
histopathological
findings
made
by
autopsy
demonstrated
the
tumor
to
be
an
adenoendocrine
cell
carcinoma
without
squamous
carcinoma
cells
.
The
case
is
interesting
in
that
the
clinical
features
were
similar
to
those
of
squamous
cell
carcinoma
of
the
gallbladder
.
Diseases
Validation
Diseases presenting
"vomiting"
symptom
22q11.2 deletion syndrome
alexander disease
alpha-thalassemia
aromatase deficiency
benign recurrent intrahepatic cholestasis
cadasil
carcinoma of the gallbladder
child syndrome
cholangiocarcinoma
congenital toxoplasmosis
cutaneous mastocytosis
dedifferentiated liposarcoma
esophageal squamous cell carcinoma
homocystinuria without methylmalonic aciduria
kallmann syndrome
locked-in syndrome
megacystis-microcolon-intestinal hypoperistalsis syndrome
neonatal adrenoleukodystrophy
primary hyperoxaluria type 1
proteus syndrome
scrub typhus
severe combined immunodeficiency
systemic capillary leak syndrome
triple a syndrome
typhoid
von hippel-lindau disease
This symptom has already been validated
