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A case of primary neuroendocrine carcinoma of the gallbladder associated with anomalous union of the pancreaticobiliary duct.
[carcinoma of the gallbladder]
Primary
neuroendocrine
carcinoma
of
the
gallbladder
is
extremely
rare
because
normal
gallbladder
mucosa
does
not
contain
neuroendocrine
cells
.
Neuroendocrine
cells
can
be
detected
at
sites
of
intestinal
metaplasia
induced
by
chronic
inflammation
,
which
may
be
the
initial
step
in
the
development
of
neuroendocrine
tumor
of
the
gallbladder
.
Anomalous
union
of
the
pancreaticobiliary
duct
(
AUPBD
)
is
an
uncommon
congenital
anomaly
that
is
frequently
associated
with
choledocholithiasis
,
cholangitis
,
pancreatitis
,
and
cancer
of
the
gallbladder
or
bile
duct
.
In
AUPBD
,
cancers
of
the
gallbladder
and
bile
duct
can
be
induced
by
chronic
inflammation
.
We
report
herein
a
case
of
large
-cell
neuroendocrine
tumor
of
the
gallbladder
associated
with
AUPBD
.
