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Simultaneous breast and ovarian metastasis from gallbladder carcinoma.
[carcinoma of the gallbladder]
Gallbladder
carcinoma
is
a
common
malignancy
in
the
Indian
subcontinent
.
It
commonly
metastasizes
through
lymphatics
,
direct
invasion
,
and
hematogenous
spread
.
A
common
extra
-
abdominal
site
of
metastasis
is
the
lungs
.
Simultaneous
metastasis
to
breast
and
ovary
is
extremely
rare
.
This
report
describes
an
unusual
case
of
carcinoma
gallbladder
metastasizing
to
the
breast
and
ovary
at
the
same
time
.
A
45
-
year
-old
woman
came
to
us
with
complaints
of
flatulent
dyspepsia
associated
with
weight
loss
and
anorexia
.
Ultrasound
of
the
abdomen
revealed
hepatomegaly
with
thick
-walled
gallbladder
with
multiple
stones
and
a
mass
at
the
fundus
,
but
normal
uterus
and
ovary
.
Contrast-enhanced
computer
tomography
of
the
abdomen
showed
a
gallbladder
mass
infiltrating
the
liver
parenchyma
.
The
patient
underwent
radical
cholecystectomy
.
Histopathological
examination
revealed
a
poorly
-differentiated
adenocarcinoma
with
mar-gins
free
from
tumor
infiltration
.
One
month
after
surgery
she
developed
a
breast
lump
.
Ultrasound
of
the
abdomen
for
metastatic
workup
revealed
an
ovary
mass
.
Simple
mastectomy
and
salphingo-opherectomy
were
performed
,
and
histopathological
examination
revealed
a
metastatic
adenocarcinoma
.
The
patient
is
now
on
chemotherapy
with
gemcitabin
.
This
is
an
unusual
case
of
carcinoma
of
the
gallbladder
with
metastasis
to
the
breast
and
ovary
,
which
has
not
been
documented
before
.