Rare Diseases Symptoms Automatic Extraction

Cushing's syndrome caused by an ACTH-producing large cell neuroendocrine carcinoma of the gallbladder.

[carcinoma of the gallbladder]

Malignancies of the gallbladder, including neuroendocrine tumors, are uncommon, mostly found incidentally after cholecystectomy and are frequently asymptomatic in the early stages, but highly fatal. Limited data is available on adrenocorticotropic hormone (ACTH)-producing neuroendocrine tumors specifically originating from the gallbladder. We report the clinical and radiographic findings, which included positron emission tomography and computed tomography, of a patient with a gallbladder mass who presented with Cushing's syndrome. Subsequently, a diagnosis of ACTH-producing large cell neuroendocrine carcinoma of the gallbladder was made. Despite being rare and having a poor prognosis, hormone-producing neuroendocrine tumors should be part of the differential diagnosis in the approach of patients with Cushing's syndrome.

Diseases presenting "early stages" symptom

  • cadasil
  • canavan disease
  • carcinoma of the gallbladder
  • erythropoietic protoporphyria
  • esophageal adenocarcinoma
  • esophageal squamous cell carcinoma
  • fabry disease
  • harlequin ichthyosis
  • holt-oram syndrome
  • omenn syndrome
  • oral submucous fibrosis
  • phenylketonuria
  • pyomyositis
  • severe combined immunodeficiency
  • von hippel-lindau disease

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