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Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder.
[carcinoma of the gallbladder]
Adenosquamous
/
squamous
cell
carcinoma
(
AS
/
SCC
)
of
the
gallbladder
is
rarely
encountered
and
accounts
for
1
.
4
-
10
.
6
%
of
all
gallbladder
carcinomas
(
GBCs
)
.
This
study
was
conducted
to
investigate
the
clinicopathologic
features
of
AS
/
SCC
of
gallbladder
.
The
authors
retrospectively
reviewed
16
cases
of
pathologically
proven
AS
/
SCC
of
the
gallbladder
among
404
patients
who
underwent
surgery
for
GBC
from
October
1994
to
March
2009
.
Forty
-
eight
conventional
GBC
patients
were
selected
as
controls
after
matching
for
age
and
gender
.
Mean
patient
age
was
60
.
2
years
and
half
were
male
.
Tumor
stages
in
the
case
group
were
significantly
more
advanced
than
the
control
group
(
P
<
0
.
001
)
.
R
0
resection
rates
in
cases
and
controls
were
50
%
and
81
.
2
%
(
P
=
0
.
022
)
.
Overall
1
-
year
survival
in
the
case
group
was
significantly
poorer
than
in
the
control
group
(
18
.
8
%
vs
.
87
.
3
%
,
P
<
0
.
001
)
.
However
,
no
significant
difference
in
disease-free
survival
rates
was
found
between
cases
and
controls
after
R
0
resection
(
P
=
0
.
072
)
.
AS
/
SCC
of
the
gallbladder
is
often
diagnosed
at
an
advanced
stage
,
which
results
in
non-curative
surgical
resection
and
a
poorer
prognosis
than
conventional
GBC
.
However
,
curative
surgical
resection
of
AS
/
SCC
of
the
gallbladder
might
result
in
disease-free
survival
rates
that
are
comparable
with
those
of
conventional
GBC
.
Diseases
Validation
Diseases presenting
"advanced stage"
symptom
carcinoma of the gallbladder
coats disease
dedifferentiated liposarcoma
erdheim-chester disease
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
inclusion body myositis
liposarcoma
oral submucous fibrosis
wiskott-aldrich syndrome
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