Curative resection of combined neuroendocrine carcinoma and adenocarcinoma of the gallbladder.

[carcinoma of the gallbladder]

Neuroendocrine carcinoma of the gallbladder has very rarely been reported as it accounts for only 0 .5 % of all neuroendocrine tumors . It has a very aggressive biological behavior . These tumors are usually diagnosed at an advanced stage and surgical management is therefore not an option . We performed a hepatopancreaticoduodenectomy along with adjuvant chemotherapy in a 48 -year -old patient with a neuroendocrine carcinoma of the gallbladder . The patient has been followed up at the outpatient clinic for 18 months without there having been any recurrence . Patients with a locally invasive neuroendocrine carcinoma in the gallbladder may benefit from aggressive surgical treatment followed by adjuvant chemotherapy . The primary management in high -grade metastatic tumors is , however , mainly medical .