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A random Abstract
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Chromosomal structural analysis in carcinoma of the gallbladder.
[carcinoma of the gallbladder]
The
etiopathogenesis
of
gallbladder
cancer
is
still
unknown
.
Both
environmental
and
patient
factors
have
been
incriminated
in
its
cause
.
That
it
is
found
in
pockets
of
epidemiological
distribution
raises
an
issue
of
genetic
changes
associated
with
it
.
The
aim
of
this
study
was
to
find
out
the
chromosomal
changes
in
gallbladder
cancer
.
Lymphocyte
cell
culture
was
carried
out
on
blood
of
gallbladder
cancer
patients
to
determine
chromosomal
banding
abnormalities
.
Native
PAGE
was
also
evaluated
to
analyze
lactate
dehydrogenase
(
LDH
)
,
superoxide
dismutase
(
SOD
)
and
catalase
enzyme
activity
from
the
same
blood
of
gallbladder
cancer
patients
.
Out
of
30
gallbladder
cancer
patients
,
4
male
showed
breakage
on
the
long
arm
of
chromosome
1
while
only
one
male
patient
showed
the
translocation
from
the
long
arm
of
chromosome
4
to
the
long
arm
of
chromosome
6
in
a
male
patient
.
The
aberrations
found
in
our
study
may
suggest
underlying
genetic
predisposition
for
the
development
of
gallbladder
cancer
.
They
can
act
as
a
marker
for
gallbladder
cancer
,
which
needs
further
study
.
