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Signet ring cell carcinoma of the gallbladder: a case report.
[carcinoma of the gallbladder]
Carcinoma
of
the
gall
bladder
is
the
most
common
biliary
tract
tumor
with
higher
incidence
in
females
and
increasing
age
.
The
risk
is
significantly
higher
in
cholelithiasis
.
Signet
ring
cell
carcinoma
is
a
rare
form
of
mucinous
adenocarcinoma
and
has
a
worse
prognosis
.
Early
diagnosis
is
rare
.
We
report
a
case
of
signet
ring
cell
carcinoma
of
the
gall
bladder
in
a
70
years
old
female
patient
.
The
gross
finding
was
yellowish
white
mass
measuring
4
x
3
.
5
cm
on
cut
surface
of
the
gall
bladder
along
with
thickened
wall
.
Histopathological
examination
of
the
specimen
shows
the
sheets
of
signet
ring
cells
with
lateral
spread
through
the
lamina
propria
and
large
amount
of
extracellular
mucin
.
There
was
metastasis
in
the
retroperitoneum
and
mesenteric
lymph
node
.
The
tumor
was
stage
IV
(
according
to
TNM
staging
)
.
Patient
died
20
th
post
operative
day
.
Since
very
few
cases
have
been
reported
,
information
regarding
the
behavior
and
prognosis
of
gall
bladder
carcinoma
is
limited
.
However
it
has
been
seen
that
stage
III
and
IV
carcinoma
usually
have
worse
prognosis
.
