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Undifferentiated spindle-cell carcinoma of the gallbladder: a report of a case, an immunohistochemistry profile, and a review of the literature.
[carcinoma of the gallbladder]
Undifferentiated
spindle-cell
carcinoma
is
a
rare
gallbladder
cancer
with
a
worse
or
similar
prognosis
to
the
generally
dismal
outcome
seen
in
most
gallbladder
cancer
patients
.
We
reported
a
case
of
SpCC
,
stage
IV
disease
that
was
initially
diagnosed
as
undifferentiated
pleomorphic
sarcoma
,
but
deeper
sections
revealed
few
clusters
of
epithelioid
clear
cells
.
Although
the
tumour
showed
biphasic
appearances
on
haematoxylin
and
eosin
,
it
exhibited
poor
protein
expression
with
most
sarcoma
markers
being
negative
except
for
focal
vimentin
positivity
.
The
CEA
and
CK
7
were
positive
only
in
the
epithelioid
clear
cell
clusters
while
CD
68
positive
was
also
focally
positive
in
the
spindle-cell
component
.
The
poor
tumour
differentiation
coupled
with
advanced
stage
at
presentation
was
partly
responsible
for
the
disease
progression
and
patients
'
death
one
year
after
surgery
.
Early
diagnosis
and
surgical
intervention
with
better
understanding
of
this
tumour
biology
may
offer
improved
prognosis
and
survival
in
this
rare
cancer
.
Diseases
Validation
Diseases presenting
"advanced stage"
symptom
carcinoma of the gallbladder
coats disease
dedifferentiated liposarcoma
erdheim-chester disease
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
inclusion body myositis
liposarcoma
oral submucous fibrosis
wiskott-aldrich syndrome
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