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Undifferentiated spindle-cell carcinoma of the gallbladder: a report of a case, an immunohistochemistry profile, and a review of the literature.
[carcinoma of the gallbladder]
Undifferentiated
spindle-cell
carcinoma
is
a
rare
gallbladder
cancer
with
a
worse
or
similar
prognosis
to
the
generally
dismal
outcome
seen
in
most
gallbladder
cancer
patients
.
We
reported
a
case
of
SpCC
,
stage
IV
disease
that
was
initially
diagnosed
as
undifferentiated
pleomorphic
sarcoma
,
but
deeper
sections
revealed
few
clusters
of
epithelioid
clear
cells
.
Although
the
tumour
showed
biphasic
appearances
on
haematoxylin
and
eosin
,
it
exhibited
poor
protein
expression
with
most
sarcoma
markers
being
negative
except
for
focal
vimentin
positivity
.
The
CEA
and
CK
7
were
positive
only
in
the
epithelioid
clear
cell
clusters
while
CD
68
positive
was
also
focally
positive
in
the
spindle-cell
component
.
The
poor
tumour
differentiation
coupled
with
advanced
stage
at
presentation
was
partly
responsible
for
the
disease
progression
and
patients
'
death
one
year
after
surgery
.
Early
diagnosis
and
surgical
intervention
with
better
understanding
of
this
tumour
biology
may
offer
improved
prognosis
and
survival
in
this
rare
cancer
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated